The ophthalmic applications group consists of two post-doctoral associates (Hu, Pan), three Graduate students (Pedersen, Lin, Ford), and one undergraduate student (Jeng). The ophthalmic group collaborates with investigators at the Cleveland Clinic Foundation (Dr. William Dupps) and the Doheny Eye Institute (Dr. David Huang).
Research Projects
Doppler OCT
Doppler optical coherence tomography (DOCT) is a functional extension of OCT that utilizes the phase of the interferometric signal to provide depth resolved measurements of velocity. Our primary focus is the imaging of retinal blood vessels.
Multi-incidence Angle OCT
OCT Screening of Donor Corneas
Corneal Biomechanics
We utilize OCT to measure the biomechanical properties of the cornea using advanced cross correlation algorithms. We are attempting to develop methods for early diagnosis and advanced understanding of corneal diseases with a mechanical component, Diseases like Keratoconus and Glaucoma. This work is performed in collaboration with ophthalmologist Dr. William Dupps of the Cole Eye Institute at the Cleveland Clinic.
Ophthalmic Application References
Publications
R. C. Lin, M. A. Shure, A. M. Rollins, J. A. Izatt, D. Huang, “Group index of the human cornea at 1.3 mm wavelength obtained in vitro by optical coherence domain reflectometry,” Optics Letters, 29, 83-85 (2004).
J. Wang, J. Thomas, I. Cox, A. M. Rollins, “Non-contact measurements of central corneal epithelial and flap thickness after laser in situ keratomileusis,” Investigative Ophthalmology & Visual Science, 45(6), 1812-1816 (2004).
J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. Patil, A. M. Rollins, J. A. Izatt, D. Huang, “Anterior Chamber Width Measurement by High-Speed Optical Coherence Tomography,” Ophthalmology; 112(2), 238-244 (2005).
S. Radhakrishnan, J. Goldsmith, D. Huang, V. Westphal, D. K. Dueker, A. M. Rollins, J. A. Izatt, S. D. Smith, “Comparison of optical coherence tomography and ultrasound biomicroscopy for detection of narrow anterior chamber angles,” Archives of Ophthalmology, 123, 1053-59 (2005).
C. J. Pedersen, V. Westphal, S. Yazdanfar, A. M. Rollins, “Phase-referenced Doppler optical coherence tomography in scattering media,” Optics Letters, 30, 2125-2127 (2005).
Selected for the August 1, 2005 issue of Virtual Journal of Biological Physics Research.
M. R. Chalita, Y. Li, S. Smith, C. Patil, V. Westphal, A. M. Rollins, J. A. Izatt, D. Huang, “High-Speed Optical Coherence Tomography of Laser Iridotomy,” Am J Ophthalmol, 140, 1133-1136, (2005).
Conference Presentations
M. Ford, W. J. Dupps, N. Huprikar, R. Lin, A. M. Rollins, "OCT corneal strain mapping by pressure-induced optical feature flow," BiOS 2006, Photonics West Conference, SPIE, San Jose, CA, January 2006
C. J. Pedersen, M. A. Shure, D. Huang, A. M. Rollins, "Measurement of absolute flow velocity vector using dual angle, delay-encoded Doppler optical coherence tomography," BiOS 2006, Photonics West Conference, SPIE, San Jose, CA, January 2006
R. C. Lin, A. M. Rollins, "Multiple incidence angle optical coherence tomography," BiOS 2006, Photonics West Conference, SPIE, San Jose, CA, January 2006
|
