The endoscopic OCT applications group in the Rollins research group currently includes two post-doctoral researchers (Dr. Hu and Dr. Pan) and two graduate students (Qi and Wang). The endoscopic OCT applications groups collaborates with investigators at GI division of University Hospitals of Cleveland (Dr. Sivak and Dr. Isenberg). These investigators are experts in gastrointerology and endoscopy.
Research Projects
Barrett’s Esophagus
The incidence of esophageal adenocarcinoma is increasing rapidly, and the major risk factor associated with this increase is Barrett’s esophagus. Barrett’s esophagus is a condition develops in some people who have chronic gastroesophageal reflux disease or imflammation of esophagus. Barrett’s esophagus has a high risk to become adenocarcinoma. Traditionally, Barrett’s esophagus designates a condition in which normal squamous mucosa is replaced by columnar epithelium, a premalignant lesion for adenocarcinoma. Adenocarcinoma in Barrett’s esophagus develops in a sequence of changes, from nondysplastic columnar epithelium, through low grade and then high grade dysplasia and finally invasive cancer.
The changing of nuclei size and shape makes the EOCT images changes. The observed EOCT characteristics of dysplasia are decreased light scattering and decreased texture architecture. And this makes the earlier detection and treatment a possibility.
Colonic Crypts
Colorectal cancer is the second leading cause of cancer-related death in the United States. Approximately 50% of these deaths could have been prevented by earlier detection through screening. The relationship between the morphological patterns of colonic crypts and histopathological diagnosis has shown close correlation. We have conducted an in vitro colonic tissue study to quantify the morphological features of colonic crypts using our microscope-integrated bench-top optical coherence tomography (OCT) scanner. This study can provide a tool for potential computer-aided in vivo colonic tissue study for screening.
Gastrointestinal Application References
Morphological feature quantification of colonic crypt pattern using microscope integrated OCT scanner, Qi, X., Pan, Y., Hu, Z., Kang, K., Sivak, M.V. Jr., Rollins, A. ----- Proceeding of Biomedical Optics Topical Meeting (BIOMED) at 2008 Spring Optics and Photonics Congress
Automated Processing and Classification of Cervical Images Using Optical Coherence Tomography, Kang,W., Qi, X., Kareta, M., Belinson, J.L., Rollins, A. ------ Proceeding of Biomedical Optics Topical Meeting (BIOMED) at 2008 Spring Optics and Photonics Congress
Morphological featuer quantification of colonic crypt patterns using microscoe integrated OCT, Qi, X., Pan, Y., Hu, Z., Kang, K., Sivak, M.V. Jr., Willis, J., Olowe, K, Rollins, A. ----- Digestive Disease Week 2008
Investigation of computer-aided colonic crypt pattern analysis --- Xin Qi, Yinsheng Pan, Michael V. Sivak, Jr., Kayode Olowe, Andrew M. Rollins --- Proceedings of SPIE bios, Jan. 2007 (paper No. 6432-17)
Computer-aided diagnosis of dysplasia in Barrett’s esophagus using endoscopic optical coherence tomography --- Xin Qi, Michael V. Sivak, Jr., Gerard Isenberg, Joseph. E. Willis, Andrew M. Rollins. Journal of Biomedical Optics 11 (4), July/August 2006
Computer-aided diagnosis of dysplasia in Barrett’s esophagus using multiple endoscopic OCT images --- Xin Qi, Douglas Y. Rowland, Michael V. Sivak, Andrew M. Rollins --- Proceeding of SPIE Bios, Jan. 2006
Computer aided diagnosis (CAD) of dysplasia in Barrett’s esophagus (BE) using endoscopic optical coherence tomography [abstract]--- Xin Qi, Michael V. Sivak, Jr., David Wilson, Andrew M. Rollins., , Gastroenterology 2004, 126, A-351
Computer aided diagnosis of dysplasia in Barrett’s esophagus using endoscopic optical coherence tomography --- paper number : 5316-07, Xin Qi, Michael V. Sivak, Jr., David Wilson, Andrew M. Rollins., Presented in SPIE Photonics West, Jan. 2004
Processing of endoscopic optical coherence tomography images for quantitative diagnosis of dysplasia --- paper number: CMN 5, Xin Qi, Michael V. Sivak, Jr., David Wilson, Andrew M. Rollins., Presented in CLEO/QELS June 2003
Image Processing of Endoscopic Optical Coherence Tomography images for quantitative diagnosis of dysplasia --- Xin Qi, Michael V. Sivak, Jr., Andrew M. Rollins (Poster in Gordon Research Conference, July 2002)
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